Neratinib (HKI-272) CAS 698387-09-6 Assay ≥98.0% (HPLC)
Ruifu Chemical is the leading supplier of Neratinib (HKI-272) (CAS: 698387-09-6) with high quality. Ruifu has been supplying APIs (active pharmaceutical ingredients) and pharmaceutical intermediates more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Neratinib or other products, please contact us by e-mail: alvin@ruifuchem.com
| Chemical Name | Neratinib |
| Synonyms | HKI-272; HKI272; HKI 272; (2E)-N-[4-[3-Chloro-4-(2-Pyridinylmethoxy)anilino]-3-Cyano-7-Ethoxy-6-Quinolinyl]-4-(Dimethylamino)-2-Butenamide |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 698387-09-6 |
| Neratinib Maleate CAS | 915942-22-2 |
| Molecular Formula | C30H29ClN6O3 |
| Molecular Weight | 557.05 g/mol |
| Melting Point | 182.0 to 186.0℃ |
| Density | 1.33 |
| Sensitive | Heat Sensitive |
| Storage Temperature | Store Long-Term at 2-8℃ |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Product Categories |
API (Active Pharmaceutical Ingredient) |
| Caution | Not For Human or Veterinary Use. For Research Use Only. |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Faint Yellow to Yellow Solid Powder | Yellow Solid Powder |
| Assay / Analysis Method | ≥99.0% (HPLC) | 99.1% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| NMR Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
| HS Code | 2933 4900.40 |
Neratinib (HKI-272) (CAS: 698387-09-6) is developed by US Wyeth company is an irreversible epidermal growth fac tor receptor(EGFR) inhibitor. Neratinib is a multiple target point of small molecule tyrosine kinase inhibitors to HER 2 and HER1 after Lapatinib, and is an irreversible ErbB receptor tyrosine kinase inhibitor. Neratinib could selectively inhibit HER-1 and HER-2 of EGFR family(IC50 was 92 nmol/L and 59 nmol/L, respectively). Clinical research showed that Neratinib exerted significant therapeutic effect on non-small cell lung cancer, colon cancer, and breast cancer. The phaseII clinical trial indicated that Neratinib showed good efficacy and tolerance to HER-2 positive patients with advanced breast cancer who had been received or not Trastuzuma b treatment.
