(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS 85977-52-2 Purity ≥99.0% e.e.≥99.0% Palonosetron Hydrochloride Intermediate Factory

Short Description:

(S)-1,2,3,4-1-Tetrahydro-Naphthoic Acid

CAS: 85977-52-2

Appearance: White or Almost White Crystalline Powder

Purity: ≥99.0% e.e≥99.0%

Intermediate of Palonosetron Hydrochloride (CAS: 135729-62-3) in the treatment of CINV

Contact: Dr. Alvin Huang

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85977-52-2 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid (CAS: 85977-52-2) with high quality, intermediate of Palonosetron Hydrochloride (CAS: 135729-62-3). Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years. Ruifu Chemical can provide competitive price, excellent service. Purchase please contact us by e-mail: alvin@ruifuchem.com

Intermediates of Palonosetron Hydrochloride:

Commercial Supply Palonosetron Hydrochloride and Related Intermediates:
(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Naphthoic Acid CAS: 86-55-5
Palonosetron Hydrochloride CAS: 135729-62-3 API

85977-52-2 - Chemical Properties:

Chemical Name	(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid
Synonyms	(1S)-1,2,3,4-Tetrahydronaphthalene-1-Carboxylic acid
CAS Number	85977-52-2
Stock Status	In Stock, Commercial Production
Molecular Formula	C11H12O2
Molecular Weight	176.21
Density	1.186±0.06 g/cm3
Melting Point	54.0~56.0℃
Boiling Point	342.7°C at 760 mmHg
Refractive Index	1.576
COA & MSDS	Available
Origin of Product	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

85977-52-2 - Specifications:

Item	Specifications
Appearance	White or Almost White Crystalline Powder
Chemical Purity	≥99.0%
Enantimoer Excess	e.e. ≥99.0%
Isomer Impurity	≤1.0%
Loss on Drying	≤0.50%
Relate Substance	≤1.0%
Moisture (K.F)	≤1.0%
Specific Rotation [α]_D²⁰	-59.0°~ -63.0°(C=0.3 in Benzence)
Heavy Metals	≤20ppm
Storage	5-8℃ Airtightness
Test Standard	Enterprise Standard
Usage	Palonosetron Hydrochloride (CAS: 135729-62-3) Intermediates

85977-52-2 - Route of Synthesis:

(S)-1,2,3,4-tetrahydro-1-Naphthoic Acid CAS: 85977-52-2 Route of Synthesis

85977-52-2 - Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

85977-52-2 - Advantages:

85977-52-2 - FAQ:

Factory Shanghai Ruifu Chemical Co., Ltd. www.ruifuchem.com

85977-52-2 - Risk and Safety:

Risk Codes R22 - Harmful if swallowed
R36 - Irritating to the eyes
R51 - Toxic to aquatic organisms
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S24/25 - Avoid contact with skin and eyes.
HS Code 2916399090

85977-52-2 - Application:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid (CAS: 85977-52-2) with high quality. It is an intermediate typically in the synthesis of Palonosetron Hydrochloride (CAS: 135729-62-3).

Palonosetron Hydrochloride (CAS: 135729-62-3) is a novel 5-HT3 receptor antagonist launched as an injectable agent for the prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy. It has a much longer half-life (~40 h) than the other currently available 5-HT3 antagonists, which provides efficacy advantages in the prevention of delayed nausea and vomiting that typically occurs after 24 h and up to six days post chemotherapy administration. With 1,2,3,4-tetrahydro-1-Naphthoic Acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.